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KMID : 0370220100540030151
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Yakhak Hoeji
2010 Volume.54 No. 3 p.151 ~ p.156
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Cytoprotective Effect of Galgeuntang Extract on Cadmium-Induced Cytotoxicity
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Park So-Yun
Baek Jong-Min
Baek Seung-Hwa
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Abstract
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Cytotoxicity of cadmium on NIH 3T3 fibroblasts was utilized in order to discover antitoxic compound in Galgeuntang extract in this study. Treatment groups were chosen as follows; control (medium only), group and five experimental groups. MTT {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide} method was performed to evaluate the cytotoxicity of cell organelles and was also measured. Accordingly we have examined the detoxification effects of Galgeuntang extract on cadmium-treated NIH 3T3 fibroblasts to observe morphological changes by the light microscopy. Galgeuntang extract showed cytoprotective effects on cadmium-induced cytotoxicity. Furthermore, Galgeuntang showed a dose-dependency in detoxication. The phenolic content of Galgeuntang ethanol extract was higher than that of water content. These results suggest that Galgeuntang extract may be used as a cytoprotective agent against cadmium (II)-mediated cytotoxicity.
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KEYWORD
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cytoprotective effect, cadmium (II)-mediated cytotoxicity, NIH 3T3 fibroblasts, Galgeuntang extract
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